GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs962856 | 1 | rs6755797 | chr2:67598633 | ETAA1 | chr2:67624442-67637533:+ | -0.17 | -4.07 | 5.59E-5 | Pancreatic cancer |
| THCA | cis | rs7590720 | 1 | rs6755934 | chr2:216907198 | MREG | chr2:216807315-216878346:- | 0.38 | 8.03 | 7.74E-15 | Alcohol dependence |
| THCA | cis | rs7590720 | 1 | rs6755934 | chr2:216907198 | PECR | chr2:216861029-216946532:- | 0.25 | 5.08 | 5.41E-7 | Alcohol dependence |
| THCA | cis | rs6547741 | 1 | rs6756238 | chr2:27841305 | FNDC4 | chr2:27714751-27718126:- | -0.15 | -3.48 | 0.000551 | Oral cavity cancer |
| THCA | cis | rs1552244 | 1 | rs67569278 | chr3:10149893 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.31 | 1.99E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs67569278 | chr3:10149893 | VHL | chr3:10183319-10193744:+ | -0.17 | -3.94 | 9.48E-5 | Alzheimer's disease |
| THCA | cis | rs9309473 | 1 | rs6756987 | chr2:73687077 | ALMS1P | chr2:73872046-73912692:+ | 0.69 | 11.05 | 2.0E-25 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6756987 | chr2:73687077 | NAT8 | chr2:73867850-73869537:- | 0.37 | 5.86 | 8.81E-9 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs6756987 | chr2:73687077 | TPRKB | chr2:73956957-73964517:- | -0.17 | -4.24 | 2.72E-5 | Metabolite levels |
| THCA | cis | rs73201462 | 1 | rs67575175 | chr3:127880226 | EEFSEC | chr3:127872313-128127488:+ | -0.26 | -4.46 | 1.03E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs7577851 | 1 | rs6757825 | chr2:69741801 | AAK1 | chr2:69685127-69870977:- | -0.24 | -5.18 | 3.35E-7 | Parkinson's disease (age of onset) |
| THCA | cis | rs7577851 | 1 | rs6757825 | chr2:69741801 | NFU1 | chr2:69623255-69664753:- | -0.18 | -3.89 | 0.000114 | Parkinson's disease (age of onset) |
| THCA | cis | rs607541 | 1 | rs675876 | chr15:45936856 | SPATA5L1 | chr15:45694519-45713614:+ | 0.3 | 4.96 | 9.8E-7 | Obesity-related traits |
| THCA | cis | rs3213787 | 1 | rs6758992 | chr2:45604509 | SRBD1 | chr2:45615820-45838433:- | -0.3 | -3.77 | 0.000182 | Glaucoma |
| THCA | cis | rs6759004 | 1 | rs6759004 | chr2:202004676 | CFLAR | chr2:201980816-202029001:+ | -0.31 | -6.35 | 5.14E-10 | Triptolide cytotoxicity |